Dr. Shuvo Roy, a Bangladeshi born American, led a team of 40 researchers in the United states which invents the world’s first implantable artificial kidney

As we learn from Wikipedia, Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal function over a period of months or years. Chronic kidney disease globally resulted in 735,000 deaths in 2010 up from 400,000 deaths in 1990.

This is the information we have in our hand for chronic kidney disease. The above statistics along with the following one in terms of the growing number of transplants is not pleasing one to read-out though.

Statistics by country, year and donor type

Country Year Cadaveric donor Living donor Total transplants
Canada 2000 724 388 1,112
France 2003 1,991 136 2,127
Italy 2003 1,489 135 1,624
Japan 2010 208 1276 1,484
Spain 2003 1,991 60 2,051
United Kingdom 2003 1,297 439 1,736
United states 2008 10,551 5,966 16,517

In this circumstance, the following pieces of information are worth referring as an article written by Gary Becker and Julio Elias on “Introducing Incentives in the market for Live and Cadaveric Organ Donations” estimated the price tag for human kidneys ($15,000); not at all a cheap figure within the reach of majority people globally.

In this situation world-wide, Dr. Shuvo Roy (Bengali: শুভ রায়), PhD, a bio engineer on the faculty of the UCSF School of Pharmacy and the technical director of The artificial kidney project, led a team of 40 researchers in nine laboratories in the United states which invents the world’s first implantable artificial kidney. After successful transplantation, this can be a potential alternative to dialysis and transplants for patients with end-stage kidney failure.

The device has shown such promise that the U.S. Food and Drug Administration selected it as one of three projects for a special fast-track approval process. Researchers hope it will be ready for a human trial in 2017.This is expected that an artificial kidney could be manufactured for $30,000 or less. Testing in animals could begin by about 2016, but it would probably be 2020 or later before the device, if proved effective, could be one to use in regular transplantation.

The artificial kidney device will cost about $20 million to develop and take it through its first clinical trial, though the team has grants and gifts of about $7 million.

The implantable device will mimic the filtration functions of a kidney as well as its ability to maintain water and salt balances, produce Vitamin D and regulate blood pressure and pH. The bio-compatible device will attach to the circulatory system and remove toxins to the bladder as waste. The device will allow patients to live untethered from dialysis machines and eat and drink more normally. Most interestingly, the device can be powered by the human body’s circulatory system.

The man behind all of these, Mr. Shuvo, was born on 10th November 1969 at Rosangiri (Bengali: রোসাংগিরি) in Fotikchori sub-district (Bengali: ফটিকছড়ি উপজেলা) in Chittagong district (Bengali: চট্টগ্রাম) of Bangladesh though some Indian media mistaken and later realized him as the citizen of India.

Mr. Shuvo is the son of Dr Ashok Nath Roy (Bengali: অশোক নাথ রায়) and Mrs. Ratna Roy (Bengali: রত্না রায়). His father is a man from Rosangiri in Fotikchori sub-district and his mother Mrs. Ratna Roy is from Alkoron of Chittagong metropolitan city.  His grandfather, Mr. Nogen Dey, was a professor of English in Sir Kanungopara Ashutosh college of Boyalkhali. He has one younger brother, Joy roy, a vascular surgeon and sister Choity roy, a anesthetic; both of them are residing in USA. His wife, Monica mathuse (Bengali: মনিকা ম্যাথুস) is an US citizen.

In his early life, Mr. Shuvo was admitted to a nursery school of Siddeshari at the age of just 5 years. But they had to go to Uganda for his father’s profession as doctor in 1974. He had completed his secondary certification from Jinja senior secondary school in Uganda. He had gone to USA and completed his under graduation from Mount union college of Oliyons. He had achieved lots of awards and honor in his life. Here is a growing list of his awards, honors, career, awarded grants, and publications thanks to www.ucsf.edu .

“Awards and Honors of Shuvo Roy

Mount Union College 1989 William and Burdella Carl Mathematics Award
Mount Union College 1992 Senior Physics Prize
Case Western Reserve University 1998 Ruth Barber Moon Graduate Student Award
Crain’s Cleveland Business 1999 Top 40 Under 40
BioMEMS and Biomedical Nanotechnology World Meeting 2001 Clinical Translation Award
Technology Review Magazine 2003 MIT TR100 Award, Top 100 Young Innovators
NASA 2004 NASA Group Achievement Award, Harsh Environment MEMS
Materials Research Society 2004 Ribbon Award, Outstanding Symposium Paper, MRS Fall Meeting
Crain’s Cleveland Business 2005 Who’s Who in Biotechnology
Cleveland Clinic 2005 Cleveland Clinic Innovator Award
Cleveland Clinic Science Internship Program 2006 Mentor Recognition Award
Cleveland Clinic 2007 Cleveland Clinic Innovator Award
Southwestern Surgical Congress 2008 Thomas G. Orr Memorial Lectureship
Biotechnology Industry Organization 2009 Biotech Humanitarian Award Finalist
Biomaterials Journal 2009 Images of the Year Selection
Vodafone Americas Foundation 2011 mHealth Alliance Award
University of California, San Francisco 2012 UCSF Outstanding Faculty Mentorship Award, Finalist
BayBio Pantheon 2012 Rising Star Award
Food and Drug Administration (FDA) 2012 Innovation Pathway 2.0 Award
Applied Innovation Institute 2013 Fellow
Heinz Awards 2013 Requested Nominator

Overview of Shuvo Roy
Shuvo Roy, PhD, is a bio engineer focusing on the development of medical devices to address unmet clinical needs through strong collaboration and a multidisciplinary approach.

Dr. Roy is a professor at the University of California, San Francisco in the Department of Bioengineering and Therapeutic Sciences (BTS), a joint department of the UCSF Schools of Pharmacy and Medicine, and is a faculty affiliate of the California Institute for Quantitative Biosciences (QB3). He is the director of the Bio design Laboratory located on the Mission Bay campus. In addition, he serves as the Technical Director of The Kidney Project and is a founding member of the UCSF Pediatric Device Consortium. He has developed and currently teaches a course on medical devices, diagnostics, and therapeutics and regularly lectures on the medical device design process to UCSF graduate students and to national and international academic and industry audiences. He is the author of more than 100 publications and co-author of three book chapters, and holds multiple patents for device developments.

Before joining UCSF in 2008, Roy co-directed the BioMEMS Laboratory in the Department of Biomedical Engineering at Cleveland Clinic in Cleveland, Ohio, focusing on clinical applications of MEMS. In 1992 he earned a BS degree, magna cum laude, for triple majors in physics, mathematics, and computer science, from Mount Union College in Alliance, Ohio. In 1995, he earned an MS in electrical engineering and applied physics and, in 2001, he earned a PhD in electrical engineering and computer science, both from Case Western Reserve University in Cleveland, Ohio.

He is the recipient of a Top 40 under 40 awards by Crain’s Cleveland Business in 1999 and the Clinical Translation Award at the 2nd Annual BioMEMS and Biomedical Nano technology World 2001 meeting. In 2003, Dr. Roy was selected as a recipient of the TR100, which features the world’s 100 Top Young Innovators as selected by Technology Review, the Massachusetts Institute of Technology’s Magazine of Innovation. In 2004, he was presented with a NASA Group Achievement Award for his work on harsh environment MEMS. In 2005, Dr. Roy was named as a Who’s Who in Biotechnology by Crain’s Cleveland Business. In 2005 and 2007, he was recognized as a Cleveland Clinic Innovator. In 2009, he was nominated for the Biotechnology Industry Organization’s Biotech Humanitarian Award, which is given in recognition of an individual who has used biotechnology to unlock its potential to improve the earth. In 2012, he was presented the Rising Star Award by BayBio Pantheon, and in that same year, he received the Innovation Pathway 2.0 Award from the Food and Drug Administration (FDA). Most recently, he was recognized as a Fellow by the Applied Innovation Institute in 2013.

Awarded Grants of Shuvo Roy
Shuvo Roy, PhD was the Principal Investigator (PI) or Co-Principal Investigator (Co-PI) for the following NIH grants.

Project Title Project Number Fiscal Year
Biocompatibility of Implantable Renal Replacement Devices 5R01EB014315-03 2014
Biocompatibility of Implantable Renal Replacement Devices 5R01EB014315-02 2013
Biocompatibility of Implantable Renal Replacement Devices 1R01EB014315-01A1 2012
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy 5R01EB008049-03 2009
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy 7R01EB008049-02 2008
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy 1R01EB008049-01 2007
Microneedle Array for Catheter Drug Delivery 7R21EB003272-02 2004
Microneedle Array for Catheter Drug Delivery 1R21EB003272-01 2003

Publications of Shuvo Roy

  1. Chung P, Heller JA, Etemadi M, Ottoson PE, Liu JA, Rand L, Roy S. Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding. J Vis Exp. 2014; (88).
  2. Kim S, Roy S. Microelectromechanical systems and nephrology: the next frontier in renal replacement technology. Adv Chronic Kidney Dis. 2013 Nov; 20(6):516-35.
  3. Kim EJ, Fleischman AJ, Muschler GF, Roy S. Response of bone marrow derived connective tissue progenitor cell morphology and proliferation on geometrically modulated microtextured substrates. Biomed Microdevices. 2013 Jun; 15(3):385-96.
  4. Humes HD, Buffington D, Westover AJ, Roy S, Fissell WH. The bioartificial kidney: current status and future promise. Pediatr Nephrol. 2014 Mar; 29(3):343-51.
  5. Fissell WH, Roy S, Davenport A. Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices. Kidney Int. 2013 Aug; 84(2):256-64.
  6. Chung P, Rowe A, Etemadi M, Lee H, Roy S. Fabric-based pressure sensor array for decubitus ulcer monitoring. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:6506-9.
  7. Etemadi M, Heller JA, Schecter SC, Shue EH, Miniati D, Roy S. Implantable ultra-low pulmonary pressure monitoring system for fetal surgery. IEEE Trans Inf Technol Biomed. 2012 Nov; 16(6):1208-15.
  8. Jelin EB, Etemadi M, Encinas J, Schecter SC, Chapin C, Wu J, Guevara-Gallardo S, Nijagal A, Gonzales KD, Ferrier WT, Roy S, Miniati D. Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2011 Jun; 46(6):1150-7.
  9. Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S. Hemocompatibility of silicon-based substrates for biomedical implant applications. Ann Biomed Eng. 2011 Apr; 39(4):1296-305.
  10. Ferrell N, Desai RR, Fleischman AJ, Roy S, Humes HD, Fissell WH. A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells. Biotechnol Bioeng. 2010 Nov 1; 107(4):707-16.
  11. Ferrell N, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH. Basal lamina secreted by MDCK cells has size- and charge-selective properties. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F86-90.
  12. Chandrana C, Talman J, Pan T, Roy S, Fleischman A. Design and analysis of MEMS based PVDF ultrasonic transducers for vascular imaging. Sensors (Basel). 2010; 10(9):8740-50.
  13. Groszek J, Li L, Ferrell N, Smith R, Zorman CA, Hofmann CL, Roy S, Fissell WH. Molecular conformation and filtration properties of anionic Ficoll. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F752-7.
  14. Melvin ME, Fissell WH, Roy S, Brown DL. Silicon induces minimal thromboinflammatory response during 28-day intravascular implant testing. ASAIO J. 2010 Jul-Aug; 56(4):344-8.
  15. Chandrana C, Kharin N, Vince G, Roy S, Fleischman A. Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers. IEEE Trans Ultrason Ferroelectr Freq Control. 2010 May; 57(5):1077-85.
  16. Datta S, Conlisk AT, Kanani DM, Zydney AL, Fissell WH, Roy S. Characterizing the surface charge of synthetic nanomembranes by the streaming potential method. J Colloid Interface Sci. 2010 Aug 1; 348(1):85-95.
  17. Fissell WH, Roy S. The implantable artificial kidney. Semin Dial. 2009 Nov-Dec; 22(6):665-70.
  18. Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Kostov YV, Roy S. Modulating human connective tissue progenitor cell behavior on cellulose acetate scaffolds by surface microtextures. J Biomed Mater Res A. 2009 Sep 15; 90(4):1198-205.
  19. Fissell WH, Hofmann CL, Ferrell N, Schnell L, Dubnisheva A, Zydney AL, Yurchenco PD, Roy S. Solute partitioning and filtration by extracellular matrices. Am J Physiol Renal Physiol. 2009 Oct; 297(4):F1092-100.
  20. Kim EJ, Boehm CA, Mata A, Fleischman AJ, Muschler GF, Roy S. Post microtextures accelerate cell proliferation and osteogenesis. Acta Biomater. 2010 Jan; 6(1):160-9.
  21. Mata A, Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Roy S. A three-dimensional scaffold with precise micro-architecture and surface micro-textures. Biomaterials. 2009 Sep; 30(27):4610-7.
  22. Conlisk AT, Datta S, Fissell WH, Roy S. Biomolecular transport through hemofiltration membranes. Ann Biomed Eng. 2009 Apr; 37(4):722-36.
  23. Nath P, Strelnik J, Vasanji A, Moore LR, Williams PS, Zborowski M, Roy S, Fleischman AJ. Development of multistage magnetic deposition microscopy. Anal Chem. 2009 Jan 1; 81(1):43-9.
  24. Ferrara LA, Gordon I, Coquillette M, Milks R, Fleischman AJ, Roy S, Goel VK, Benzel EC. A preliminary biomechanical evaluation in a simulated spinal fusion model. Laboratory investigation. J Neurosurg Spine. 2007 Nov; 7(5):542-8.
  25. Melnik K, Sun J, Fleischman A, Roy S, Zborowski M, Chalmers JJ. Quantification of magnetic susceptibility in several strains of Bacillus spores: implications for separation and detection. Biotechnol Bioeng. 2007 Sep 1; 98(1):186-92.
  26. Fissell WH, Manley S, Dubnisheva A, Glass J, Magistrelli J, Eldridge AN, Fleischman AJ, Zydney AL, Roy S. Ficoll is not a rigid sphere. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1209-13.
  27. Fissell WH, Fleischman AJ, Humes HD, Roy S. Development of continuous implantable renal replacement: past and future. Transl Res. 2007 Dec; 150(6):327-36.
  28. Mata A, Boehm C, Fleischman AJ, Muschler GF, Roy S. Connective tissue progenitor cell growth characteristics on textured substrates. Int J Nanomedicine. 2007; 2(3):389-406.
  29. Fissell WH, Manley S, Westover A, Humes HD, Fleischman AJ, Roy S. Differentiated growth of human renal tubule cells on thin-film and nanostructured materials. ASAIO J. 2006 May-Jun; 52(3):221-7.
  30. Smiechowski MF, Lvovich VF, Roy S, Fleischman A, Fissell WH, Riga AT. Electrochemical detection and characterization of proteins. Biosens Bioelectron. 2006 Dec 15; 22(5):670-7.
  31. Schneider T, Moore LR, Jing Y, Haam S, Williams PS, Fleischman AJ, Roy S, Chalmers JJ, Zborowski M. Continuous flow magnetic cell fractionation based on antigen expression level. J Biochem Biophys Methods. 2006 Jul 31; 68(1):1-21.
  32. Talman JR, Fleischman AJ, Roy S. Orthogonal-coil RF probe for implantable passive sensors. IEEE Trans Biomed Eng. 2006 Mar; 53(3):538-46.
  33. Lopez CA, Fleischman AJ, Roy S, Desai TA. Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells. Biomaterials. 2006 Jun; 27(16):3075-83.
  34. Benzel EC, Kayanja M, Fleischman A, Roy S. Spine biomechanics: fundamentals and future. Clin Neurosurg. 2006; 53:98-105.
  35. Mata A, Fleischman AJ, Roy S. Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems. Biomed Microdevices. 2005 Dec; 7(4):281-93.
  36. Nath P, Roy S, Conlisk T, Fleischman AJ. A system for micro/nano fluidic flow diagnostics. Biomed Microdevices. 2005 Sep; 7(3):169-77.
  37. Benzel E, Ferrara L, Roy S, Fleischman A. Micromachines in spine surgery. Spine (Phila Pa 1976). 2004 Mar 15; 29(6):601-6.
  38. Mata A, Su X, Fleischman AJ, Roy S, Banks BA, Miller SK, Midura RJ. Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins. IEEE Trans Nanobioscience. 2003 Dec; 2(4):287-94.
  39. Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S. Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces. J Biomed Mater Res. 2002 Dec 15; 62(4):499-506.
  40. Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S. Analysis of connective tissue progenitor cell behavior on polydimethylsiloxane smooth and channel micro-textures. Biomed Microdevices. 2002 Dec; 4(4):267-75.
  41. Kotzar G, Freas M, Abel P, Fleischman A, Roy S, Zorman C, Moran JM, Melzak J. Evaluation of MEMS materials of construction for implantable medical devices. Biomaterials. 2002 Jul; 23(13):2737-50.
  42. Benzel EC, Ferrara LA, Roy S, Fleischman AJ. Biomaterials and implantable devices: discoveries in the spine surgery arena. Clin Neurosurg. 2002; 49:209-25.”

The project on Web: http://kidney.ucsf.edu/
On Facebook: https://www.facebook.com/ArtificialKidney
On Twitter: https://twitter.com/kidneyproject

Address:
The Kidney Project, Box 2520, Room BH203A,
University of California, San Francisco
San Francisco, California 94143

Support to kidney project: https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_AppealGivingForm&Primary=Pharmacy&Allocation=Artificial%20Kidney%20Project&AppealCode=PKW11&AllocationCode=B2915&SchoolCode=PHA

Reference:
http://en.wikipedia.org
http://www.ucsf.edu/

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About mahfujalam

This is Mahfuj Alam, Bangladesh. Working in the field of information technology, development.

Posted on October 12, 2014, in Personality and tagged , , , , , , , , . Bookmark the permalink. Leave a comment.

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